One issue with removing and installing the scope is making sure it's mounted in the exact same position and orientation, and the screws are torqued the same each time. Depending on the scope quality, if the reticle is not perfectly concentric, centered in the optic, if it's rotated even slightly since the last time it was zeroed it will need to be zeroed again. It's not uncommon for inexpensive scopes to lose zero just from the rifle's recoil.
The only issue on the 10/22 takedown is to make sure the barrel/receiver adjustment is made correctly when the rifle is first set up. Back off the barrel adjustment knob, assemble rifle, tighten adjustment knob, disassemble rifle, tighten adjustment knob 1-2 additional clicks. There should be resistance when assembled again assuring the barrel and receiver will now be aligned every time.