My thoughts...everybody has their own.
If I absolutely had no other choice, I would take the .22. I have a SR22 and love it, great range fun gun, kids love it. Will it kill ? Sure.
Would you use it to hunt 70 lb Coyote, or even a 150-200 lb deer?
I personally want a round that will stop ,in his tracks, a BG ,whom ,if high on sumpin, may not even feel the .22 for a while.
IF you have time in a defensive situation, SD or HD, to place a .22 perfectly, it still doesnt have that energy to STOP a big ole BG in his tracks.
Some situations, it MAY scare the BG off, but may not. I dont want to take that chance ,when protecting myself , and especially my family.
I CCW a Bulldog .44 spcl with Hornady SD ammo, and seriuosly looking at moving to .45 acp.
I know stingers are high velocity, but look at the ballistics....not enough energy for me.
You sir, now have my thoughts.

Jim