Regardless of the platform, model or chambering, it's shot placement that matters most. I know a couple folks that use these for small and med game hunting although for whatever reason, most seem to believe they need the latest ultra super maxi-magnum for anything above a rabbit.
I have used it to with a 60gr Nosler Partitions to fill a doe tag in Florida (it is legal here). It was a quick kill on about 100 lb doe at 40 yards. Pretty normal here in NE FLA.
It is not what I would normally use in another state or high in a tree with 200yd+ visibility. I know some will hurl insults about using this caliber at all on deer but notice that I was using it for a very specific application and if a Monster Buck (yeah, right in Fla) had come into the plot My scoped 454 Casull would have been called into action.
That 60 gr Nosler partition is the only thing I would use if hunting anything bigger than a coyote.