I have the LR and magnum versions, both with the 22 in. barrel, The LR has a 4x Nikon Prostaff and the magnum has a 4 to 9 Prostaff, they are both accurate and the LR model also works perfect with the BX15 and BX25 magazines. I am completely happy with both, but am considering a CZ .17 HMR for a little variety.
I have the CZ Lux along with a pile of 10/22's. The CZ is an awesome gun that is crazy accurate and very well built. The 10/22's are great little guns that I feel are built well also, but they aren't as accurate. It really boils down to what you want. If you want to sit down at a bench and put five shots in a dime sized group at 50 yards, the CZ is definitely your gun. If you want a fun semi-auto that you can customize to your taste, a 10/22 can't be beat. I like them both equally for the purposes they serve
The CZ is definitely a gun that can do that straight from the box. I'd recommend getting your hands on several different types of ammo to see what patterns best for your gun (once you get it of course). I found that my gun really prefers the SK ammo and that 1/3" five shot groups at 50 yards were pretty typical if I could do my part. Once you find the ammo, buy you a bulk pile of it and you'll bet all set.
A 10/22 can be set up to shoot quite accurately, but you'll have to replace almost every part to get in the accuracy range of the stock CZ. I've yet to see a modified 10/22 that shoots as well as a stock CZ. Not saying that they don't exist, I just haven't seen one.
I bought a American in .22 Mag, put a Nikon Prostaff on it and bore sighted it. Walked out into backyard and took the head off a squirrel. It got stolen from me and I didn't hesitate in buying another.